4Bases
4bases is a Swiss biotechnology company (based in Manno, founded in 2013) dedicated to the development, production, and marketing of genomic sequencing reagent kits and data analysis solutions for precision medicine and genetic research.
Its main products are NGS (next-generation sequencing)-based sequencing kits, genomic analysis software, and protocols used to identify hereditary mutations, cancer predispositions, and other relevant genetic changes.
4bases kits are compatible with Oxford Nanopore sequencing technologies, allowing them to be used with devices such as MinION, GridION, or PromethION for rapid and flexible analysis in human genetics and cancer.
PRODUCTS
4bases BRaCA panel is a amplicon-based kit for rapid and cost-effective identification of
germline and somatic variations (SNVs, indels, CNVs) in BRCA-related cancer.
It allows the identification of mutations in BRCA1 and BRCA2 genes through Next Generation
Sequencing(NGS).
The kit is validated for the analysis of DNA extracted from blood and tissue samples (fresh, frozen or FFPE). Compatible with Oxford Nanopore Technologies.
4bases HEVA pro is a genomic analysis kit for oncology, designed to identify mutations in genes associated with hereditary breast and ovarian cancer (HBOC), Lynch syndrome (HNPCC), familial adenomatous polyposis (FAP), and other hereditary tumor syndromes.
HEVA pro includes genes involved in homologous recombination repair (HRR), mismatch repair (MMR), and other key pathways in cancer predisposition, such as tumor suppressor genes, rare syndrome-associated genes, and oncogenes with therapeutic relevance.
It is ideal for characterizing hereditary and somatic variants in cancer-related diseases, facilitating risk stratification and drug selection.
The kit is designed for germline and somatic (SNV, CNV) analysis of DNA extracted from blood samples and cancerous tissues (fresh, frozen, or FFPE). Compatible with Oxford Nanopore Technologies.
4bases BENKit panel is an amplicon-based kit designed to enable comprehensive analysis for profiling hot spots relevant to customized plans selection in metastatic colorectal cancer and non-small cell lung carcinoma.
These key mutations are located in the following genes: KRAS, NRAS, BRAF, EGFR, and PIK3CA—well-known drivers and biomarkers in precision oncology.
The kit is validated for somatic analysis (SNPs, indels) of DNA extracted from cancer tissues
(fresh, frozen or FFPE). Compatible with Oxford Nanopore Technologies.
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Fusion Pro is a research kit specifically designed for the detection of clinically relevant gene fusions and associated transcriptomic alterations in cancer.
Fusion events originate from structural genomic rearrangements that juxtapose coding regions of two previously independent genes. These alterations are highly prevalent in sarcomas and hematologic malignancies and are increasingly recognized in a wide range of solid tumors.
Fusion Pro targets fusions involving tyrosine kinases, chromatin remodelers, and transcription factors—key oncogenic drivers that can lead to the activation of constitutive pathways and tumor progression. By focusing on clinically viable fusion transcripts, the panel enables:
• Precise identification of attention targets,
• Detection of biomarkers with prognostic value and selection,
• Transcription-level resolution of fusion-driven oncogenesis,
• Minimization of the detection of artifacts or irrelevant fusions.
The assay is validated for somatic RNA-based analysis, including SNVs, indels, and fusion transcripts, from multiple sample types: whole blood, fresh or frozen tissue, and FFPE samples.
This makes Fusion Pro an essential tool for precision cancer research, supporting prognostic and therapeutic decision-making. Compatible with Oxford Nanopore Technologies.
4bases HRD pro is a kit for the identification of mutations in genes related to the homologous recombination and repair (HRR) pathway.
HRD pro enables the detection of variants associated with homologous recombination deficiency (HRD), a key mechanism driving genomic instability in cancer. HRD leads to error-prone DNA repair pathways, increasing susceptibility to PARP inhibitors and platinum-based chemotherapy.
The kit is validated for germline and somatic analysis (SNVs, indels, CNVs, CNAs, HRD Score) of DNA extracted from blood samples and cancer tissues (fresh, frozen or FFPE). Compatible with Oxford Nanopore Technologies.
PanCancer Pro is a certified kit designed for comprehensive molecular profiling of clinically relevant
variants im-plicated in the onset, progression, and response of solid tumors.
The panel targets a curated selection of genes with established roles in tumorigenesis, response, prognosis, and hereditary cancer syndromes. By focusing on actionable mutations and applying an optimized design, it ensures high sensitivity and specificity while minimizing background from non-actionable
alterations.
This approach provides oncologists and geneticists with robust, clinically meaningful insights, facilitating:
• Precise determination of the individual plan,
• Refined prognostic stratification,
• Accurate assessment of hereditary cancer risk
• Streamlined interpretation with reduced noise
PanCancer Pro thus delivers maximum clinical utility without unnecessary complexity, making it a reliable decision-support tool across diverse oncology workflows.
The kit is validated for germline and somatic analysis (SNPs, indels, CNVs) of DNA extracted from blood or body tissues samples (fresh, frozen, FFPE).
Pancancer pro allows detection of variants linked to 88 genes. Compatible with Oxford Nanopore Technologies.
HEMATO pro is a kit designed for the analysis of complex genomic variants associated with lymphoid and myeloid diseases.
The kit is validated for the analysis of germline and somatic DNA (SNVs, indels, CNVs, and ITDs) extracted from blood samples.
HEMATO pro is a kit for the analysis of 146 genes frequently mutated in hematologic malignancies.
These genes can be classified into two main groups: myeloid-associated genes and lymphoid-associated genes.
The identification of recurrent genetic mutations has transformed clinical approaches, refined prognostic stratification, and enabled targeted specific interventions. Compatible with Oxford Nanopore Technologies.
4bases CFTR panel is an amplicon-based solution for rapid and cost-effective identification of known and novel germline variations (CNVs, SNPs, indels, poly-T and TG repeats) in the CFTR gene.
It allows the identification of the most common, well-known causative mutations of the CFTR gene, new exonic and deep intronic variants, through Next Generation Sequencing (NGS).
The kit is validated for the analysis of DNA extracted from blood (also from dried blood spot) Compatible with Oxford Nanopore Technologies.
4bases FH panel is a amplicon-based assay for the rapid and cost-effective detection of well-known and novel germline variants associated with familial hypercholesterolemia.
It targets 9 relevant genes and includes the analysis of SNPs related to polygenic risk and statin response using Next Generation Sequencing (NGS).
The kit is validated for use with DNA extracted from blood samples. Compatible with Oxford Nanopore Technologies.
Compatible with Oxford Nanopore Technologies.
The THALASSEMIA panel is a amplicon-based kit designed for the efficient detection of the most common variants associated with a- and b-thalassemia in a single workflow. It targets the HBA1, HBA2, and HBB genes and enables identification of SNVs, small indels, and large exonspanning CNVs through Next Generation Sequencing (NGS).
The kit is validated for use with DNA extracted from blood samples. Compatible with Oxford Nanopore Technologies.
4bases CARDIO pro is a capture-based kit designed for the comprehensive genetic characterization of familial cardiovascular diseases.
It includes 232 curated genes (coding regions + 100 bp padding) linked to cardiomyopathies, channelopathies, rare cardiac conditions, and hereditary aneurysmal syndromes, following current clinical
guidelines (e.g. ClinGen), with optional coverage of mitochondrial genes (ref. MitoMap).
The kit enables the detection of SNVs and CNVs through Next Generation Sequencing (NGS) from germline
DNA samples (blood or tissues). Compatible with Oxford Nanopore Technologies.
4bases ClinEX pro is a kit designed to detect genetic factors responsible of disease conditions not attributable to known pathologies, genetically heterogeneous diseases, and complex syndromic pictures.
The kit targets more than 10,000 genes described in OMIM as related to known pathologies, with optional coverage of mitochondrial genes (ref. MitoMap), plus ~130 hotspots, SNPs, deep intronic regions with
a correlation to known hereditary diseases.
The kit enables the detection of SNVs and CNVs through Next Generation Sequencing (NGS) from germline
DNA samples (blood or tissues). Compatible with Oxford Nanopore Technologies.
Neoscreen pro is a research kit that enables the screening of clinically significant genes, including genes associated with inherited diseases, in newborns.
Neoscreen pro is an advanced NGS-based panel designed for the early detection of genetic diseases in newborns, providing information on more than 400 genes associated with inherited disorders. The panel focuses on diseases where early detection and treatment improve prognosis and quality of life.
This comprehensive solution facilitates the identification of metabolic diseases, primary immunodeficiencies, hemoglobinopathies and hematological disorders, endocrine disorders, neuromuscular diseases and other genetic syndromes, as well as rare diseases.
Early detection through genomic screening allows for timely intervention, personalized medical planning, and improved long-term outcomes. Thanks to its broad genetic coverage and high analytical sensitivity, Neoscreen pro is a powerful tool in the transition to early intervention.
The kit is validated for germline analysis (SNPs, indels, CNVs) of DNA extracted from blood or body tissues (fresh or frozen) or DBS samples. Compatible with Oxford Nanopore Technologies.
4bases NEPHRO pro is a comprehensive genetic solution designed to support the screening of inherited kidney diseases. It is specifically developed for the evaluation of nephrotic syndromes, cystic kidney disease, tubular and glomerular dysfunctions, and for genetic assessment in kidney transplantation, enabling the detection of a wide range of clinically relevant genetic variants.
By identifying pathogenic variants in affected individuals, at-risk relatives, or transplant candidates, the Nephro pro kit facilitates early detection, personalized medicine, transplant risk stratification, and genetic counseling.
The kit is validated for germline analysis (SNPs, indels, CNVs) of DNA extracted from blood or body tissue samples (fresh, frozen, etc.). Compatible with Oxford Nanopore Technologies.
4bases RIDS Pro is a kit, a high-resolution, NGS-based capture panel designed to investigate genetic variations involved in immune pathways and support personalized medicine. RIDS Pro enables the detection of germline variants in key immune signaling pathways: cytokine signaling, interferon pathways, innate immune activation, immune checkpoints, and antigen processing and presentation.
By integrating RIDS Pro into transplant and infectious disease workflows, clinicians gain critical insights into immunogenetic landscape. This enables personalized plans, proactive risk management, and ultimately supports improved outcomes for infectious disease prevention.
Validated for germline analysis (SNPs, indels, CNVs) of DNA extracted from blood or tissue samples. Compatible with Oxford Nanopore Technologies.
WES Pro is an in vitro screening medical device for enzyme fragmentation, library preparation, target enrichment, and targeted capture of the coding regions of over 22,000 genes in the human genome (more than 99% of protein-coding genes), with optional mitochondrial gene coverage (ref. MitoMap).
The kit enables the preparation of next-generation sequencing (NGS)-compatible exome libraries from germline DNA samples (blood or tissue).
WES Pro guarantees the highest quality standards for exome-enriched library preparation in the laboratory workflow. Compatible with Oxford Nanopore Technologies.
4bases WholEX pro is a capture-based kit designed for high-resolution analysis of the human exome in clinical and research settings.
It targets the coding regions of over 22,000 genes, covering more than 99% of known protein-coding sequences, with the option to include mitochondrial genes based on MitoMap references. This broad
coverage supports the investigation of a wide range of genetic disorders, both common and rare.
The kit enables the simultaneous detection of single nucleotide variants (SNVs) and copy number variations
(CNVs) through Next Generation Sequencing (NGS) from germline DNA extracted from blood or fresh/frozen
tissue samples. Compatible with Oxford Nanopore Technologies.
Compatible with Oxford Nanopore Technologies.
Oxford Nanopore MICROBIOME PLUS panel LONG
Compatible with Oxford Nanopore Technologies.
Oxford Nanopore MICROBIOME WGS
Compatible with Oxford Nanopore Technologies.